AT-121
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2099681-31-7
≥95%
A solution in chloroform
C24H38N4O3S
462.64968
n-[2-[1,2-
- MSDS: View or download
A dual µ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively); stimulates [35S]GTPγS binding to cell membranes expressing µ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively); decreases capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys from 0.003-0.03 mg/kg; lacks reinforcing effects and reduces oxycodone reinforcement in a drug self-administration assay in rhesus monkeys from 0.3-10 µg/kg per injection; does not induce hyperalgesia in rhesus monkeys at 0.01 or 0.03 mg/kg
