Boromycin

A boron-containing macrolide antibiotic; inhibits growth of B. subtilis (MIC = 0.05 µg/ml); decreases the synthesis of protein, RNA, and DNA in B. subtilis at 0.05 µg/ml; inhibits the growth of B. halodurans (MIC = 10 ng/ml); reverses bleomycin-induced cell cycle arrest at the G2 phase in Jurkat cells at 3.4 nM; inhibits replication of the HIV-1 strains LAV-1 and RF and the HIV-2 strain LAV-2 in MT-4 cells (IC50s = 0.008, 0.11, and 0.007 µM, respectively); inhibits replication of a clinical isolate of HIV-1, strain KK-1, in MT-4 cells and PBMCs (IC50s = 0.14 and <0.1 µM, respectively)