Triciribine

An Akt activation inhibitor and a prodrug form of triciribine phosphate; reduces levels of phosphorylated Akt1, -2, and -3 in Akt-overexpressing NIH3T3 cells at 1 µM; is selective for Akt1, -2, and -3 over a panel of seven other Akt-activating kinases at 1 µM; reduces proliferation of L1210 cells at 0.05, 0.2, and 1 µM; induces cell cycle arrest at the G1 phase in L1210 cells at 1 µM; reduces viral plaque formation in CEM-SS cells and HFFs infected with HIV-1 and CMV, respectively (IC50s = 0.02 and 2 µM, respectively); inhibits tumor proliferation in an OVCAR-3 mouse xenograft model at 1 mg/kg per day