6,7-dihydroxy Bergamottin
Catalogue number:
CAY10009598-25 mg
Supplier:
Size:
25 mg
Product is available in:
£406.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
145414-76-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H24O6
Molecular Weight:
372.4
Alternative Names:
4-
Product Description:
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).{14836} It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.{14571,14836} However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
