6,7-dihydroxy Bergamottin
Catalogue number:
CAY10009598-1 mg
Supplier:
Size:
1 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
145414-76-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H24O6
Molecular Weight:
372.4
Alternative Names:
4-
Product Description:
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).{14836} It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.{14571,14836} However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
