JTE-013
Catalogue number:
CAY10009458-10 mg
Supplier:
Size:
10 mg
Product is available in:
£189.00
Estimated delivery Wed 17 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
383150-41-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C17H19Cl2N7O
Molecular Weight:
408.3
Alternative Names:
n-
Product Description:
An S1P2 and S1P4 receptor antagonist (IC50 = 17 and 237 nM, respectively); selective for S1P2 over S1P1 and S1P3 (IC50s = >10 µM for both); reverses S1P-induced inhibition of HUVEC and SMC migration at 1 and 10 µM; reverses S1P-induced inhibition of B16 murine melanoma cell migration; reduces lung injury, endothelial dysfunction, and pulmonary edema in a rat model of cecal ligation and puncture-induced sepsis at 30 mg/kg; inhibits DES1 (IC50 = 16.8 µM), as well as SK1 and SK2 (IC50s = 25.1 and 4.3 µM, respectively)
