Genistein

An isoflavonoid phytoestrogen with kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties; inhibits EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively); reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model at 50 mg/kg per day; increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by DES at 50 mg/kg per day administered on postnatal days 1-5; reduces lipid accumulation and inflammation in the liver of OVX and non-OVX female rats in a model of high-fat high-fructose diet-induced model of NASH at 16 mg/kg per day; inhibits HIV-1 DNA synthesis in resting CD4+ T cells at 10 µM