YK-11
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1370003-76-1
≥95% (mixture of diastereomers)
A crystalline solid
C25H34O6
430.53386
(20e)-17α,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid, methyl ester
A partial agonist of the androgen receptor; activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors at 0.1 µM; induces expression of FKBP51 and FGF18 in HEK293 cells at 10 µM; accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini; increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as Fst, and induces myogenic differentiation in C2C12 cells at 500 nM; accelerates proliferation and mineralization and increases expression of osteoblast differentiation markers in MC3T3-E1 mouse osteoblast cells
