AMG 232
Catalogue number:
CAY25667-5 mg
Supplier:
Size:
5 mg
Product is available in:
£353.00
Estimated delivery Mon 23 Feb
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1352066-68-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C28H35Cl2NO5S
Molecular Weight:
568.55264
Alternative Names:
(3r,5r,6s)-5-
Product Description:
An inhibitor of the MDM2 and p53 interaction (KD = 0.045 nM; IC50 = 0.6 nM in a cell-free binding assay); inhibits proliferation of HCT116 p53 wild-type, but not p53-/-, cells (IC50s = 10 nM and >25 µM, respectively); reduces tumor growth in an SJSA-1 osteosarcoma mouse xenograft model (ED50 = 9.1 mg/kg); induces complete regression of tumors in an SJSA-1 osteosarcoma mouse xenograft model at 75 mg/kg per day for 10 days; induces apoptosis of SJSA-1 mouse xenograft tumor cells
