AMG 232
Catalogue number:
CAY25667-5 mg
Supplier:
Size:
5 mg
Product is available in:
£353.00
Estimated delivery Wed 3 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1352066-68-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C28H35Cl2NO5S
Molecular Weight:
568.55264
Alternative Names:
(3r,5r,6s)-5-
Product Description:
An inhibitor of the MDM2 and p53 interaction (KD = 0.045 nM; IC50 = 0.6 nM in a cell-free binding assay); inhibits proliferation of HCT116 p53 wild-type, but not p53-/-, cells (IC50s = 10 nM and >25 µM, respectively); reduces tumor growth in an SJSA-1 osteosarcoma mouse xenograft model (ED50 = 9.1 mg/kg); induces complete regression of tumors in an SJSA-1 osteosarcoma mouse xenograft model at 75 mg/kg per day for 10 days; induces apoptosis of SJSA-1 mouse xenograft tumor cells
