CEP-40783

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A multi-kinase inhibitor; inhibits Axl and c-MET (IC50s = 7 and 12 nM, respectively); inhibits Axl in 293GT cells expressing Axl and c-MET in NCI H1299 NSCLC cells (IC50s = 0.26 and 6 nM, respectively); inhibits TYRO3 and MER (IC50s = 3.5 and 1.89 nM, respectively); induces complete regression of tumors in an Axl/NIH3T3 mouse xenograft model at 0.3 mg/kg; induces tumor stasis and regression in an EBC-1 NSCLC mouse xenograft model at 3 and 10 mg/kg, respectively; reduces tumor growth in an MC38 mouse syngeneic model concomitantly with innate and adaptive immune cell activation