4-octyl Itaconate
Catalogue number:
CAY25374-50 mg
Supplier:
Size:
50 mg
Product is available in:
£121.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
3133-16-2
Purity:
≥98% (mixture of tautomers)
Formulation:
A crystalline solid
Molecular Formula:
C13H22O4
Molecular Weight:
242.3
Alternative Names:
2-methylene-
Product Description:
A prodrug form of itaconate; hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages; increases Nrf2 protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages; decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice at 50 mg/kg
