Methidathion
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950-37-8
≥98%
A solid
C6H11N2O4PS3
302.334381
s-[(5-methoxy-2-oxo-1,3,4-thiadiazol-3(2h)-yl)methyl]phosphorodithioic acid, o,o-dimethyl ester
An organophosphate insecticide; inhibits insect cholinesterase; reduces cattle lice (L. vituli, D. bovis, and H. eurysternus) infestation by 99.1% at 3.5 mg/kg; selectively toxic to lice over cattle, only inhibiting cattle plasma acetylcholinesterase activity by 20% with no effect on survival at 24 mg/kg; increases SCE and induces cell cycle arrest at the M1 phase in V79 cells at 40 µg/ml; increases liver enzyme activity, inhibits cholinesterase, and induces chronic liver inflammation in male beagle dogs from 1.4-4.7 mg/kg; induces loss of striation and myocytolysis of cardiomyocytes and reduces serum cholinesterase activity in rats 5 mg/kg
