Isosakuranetin

A citrus flavanone with diverse biological activities; inhibits PregS-induced calcium uptake in HEK293 cells expressing mouse TRPM3 (IC50 = 50 nM); selective for TRPM3 over TRPM1, TRPM8, and TRPV1 at 10 µM; increases latency to first pain-related response in mice in a hot plate test and reduces the number and duration of PregS-induced nocifensive responses in mice at 2 mg/kg; reduces systolic blood pressure in spontaneously hypertensive rats at 10 mg/kg; inhibits UV-B-induced MMP-1 expression by 90% in HaCaT cells at 20 µM and inhibits phosphorylation of ERK1/2 at 50 µM; blocks hydrogen peroxide-induced increases in ROS, intracellular calcium concentration, caspase-3 activity, and JNK phosphorylation, as well as decreases in catalase activity, in PC12 cells at 0.8 µM; has antibacterial and trypanocidal activity against M. tuberculosis, C. neoformans, and T. cruzi