Tosedostat
Catalogue number:
CAY23395-1 mg
Supplier:
Size:
1 mg
Product is available in:
£114.00
Estimated delivery Fri 2 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
238750-77-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H30N2O6
Molecular Weight:
406.5
Alternative Names:
αs-[[(2r)-2-
Product Description:
An aminopeptidase inhibitor (IC50s = 100, 150, and 220 nM for LAP, PUSA, and aminopeptidase N, respectively); inhibits proliferation of human leukemia cell lines in vitro irrespective of p53, PTEN, or K-RAS mutational status (IC50s = 10-770 nM); induces up-regulation of genes in amino acid transport and metabolic pathways and inhibits phosphorylation of mTOR substrates in HL-60 cells; reduces total tumor burden and the number of spontaneous metastases in a mouse MDA-MB-435 xenograft model when administered at a dose of 100 mg/kg
