TMP-195
Catalogue number:
CAY23242-5 mg
Supplier:
Size:
5 mg
Product is available in:
£176.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1314891-22-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C23H19F3N4O3
Molecular Weight:
456.4
Alternative Names:
n-[2-methyl-
Product Description:
A class IIa HDAC inhibitor (Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively); selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 µM for HDAC1-3, 6, 9, and 10-11); blocks accumulation of CCL2 in the supernatant of CSF-1-stimulated monocytes; increases secretion of CCL1 by CSF-1 and GM-CSF-stimulated monocytes; reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer
