Streptomycin (sulfate)

An aminoglycoside antibiotic; inhibits growth of Gram-negative (MICs = 1.0 and 16 µg/mL for K. pneumoniae and S. marcescens, respectively) and Gram-positive bacteria (MIC = 0.25 µg/mL for S. pneumoniae); inhibits growth of M. tuberculosis H37Rv (MIC = 5 µg/mL) and of susceptible strains from clinical isolates (MICs = ≤0.125-1 µg/mL); once weekly administration at a dose of 150 mg/kg in combination with isoniazid, rifapentine, and moxifloxacin over 6 months to M. tuberculosis-inoculated mice results in clearance of the pathogen from the lungs in the majority of treated mice; however, after 3 months without treatment, 58% of treated mice produce a positive lung culture; used in antibiotic cocktails to prevent bacterial growth in cell culture