SLC5111312 (hydrochloride)
Catalogue number:
CAY23288-1 mg
Supplier:
Size:
1 mg
Product is available in:
£140.00
Estimated delivery Fri 20 Feb
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1870811-01-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H27N5O3 • HCl
Molecular Weight:
445.94232
Alternative Names:
(2s,3s)-3-
- MSDS: View or download
Product Description:
A dual SPHK1 and SPHK2 inhibitor (Kis = 0.73 and 0.9 µM, respectively, using human recombinant kinases); selective for Sphk2 over Sphk1 in mice (Kis = 1 and 20 µM, respectively); not selective in rat (Kis = 1.1 and 0.8 µM for Sphk2 and Sphk1, respectively); decreases S1P in vitro at concentrations of 0.1 and 0.3 µM; decreases S1P in Sphk1-/- knockout mice and in rat at a dose of 10 mg/kg
