UNC569
Catalogue number:
CAY22966-5 mg
Supplier:
Size:
5 mg
Product is available in:
£199.00
Estimated delivery Wed 10 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1350547-65-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H29FN6
Molecular Weight:
396.5
Alternative Names:
1-[(trans-4-
- MSDS: View or download
Product Description:
A TAM family kinase inhibitor (IC50s = 2.9, 37, and 48 nM for Mer, Axl, and Tyro3, respectively); antiproliferative against ALL cells (IC50s = 0.5 and 1.2 µM for 697 and Jurkat cell lines, respectively); inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively); decreases tumor burden by 47.8% relative to controls in human MYC transgenic zebrafish (4 µM); delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells (10 mg/kg)
