PF-4693627
Catalogue number:
CAY22768-500 ug
Supplier:
Size:
500 µg
Product is available in:
£52.00
Estimated delivery Wed 18 Feb
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1312815-93-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C26H29Cl2N3O3
Molecular Weight:
502.4
Alternative Names:
1-[5-chloro-6-
Product Description:
An orally bioavailable mPGES-1 inhibitor (IC50 = 3 nM); selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values >50 µM, as well as COX-2 in fetal fibroblasts (IC50 = >10 µM); inhibits LPS-stimulated synthesis of PGE2 in human whole blood (IC50 = 109 nM); inhibits PGE2 production in a guinea pig model of carrageenan-induced air pouch inflammation (10 mg/kg)
