PF-4693627
Catalogue number:
CAY22768-5 mg
Supplier:
Size:
5 mg
Product is available in:
£444.00
Estimated delivery Fri 9 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1312815-93-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C26H29Cl2N3O3
Molecular Weight:
502.4
Alternative Names:
1-[5-chloro-6-
Product Description:
An orally bioavailable mPGES-1 inhibitor (IC50 = 3 nM); selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values >50 µM, as well as COX-2 in fetal fibroblasts (IC50 = >10 µM); inhibits LPS-stimulated synthesis of PGE2 in human whole blood (IC50 = 109 nM); inhibits PGE2 production in a guinea pig model of carrageenan-induced air pouch inflammation (10 mg/kg)
