Afobazole (hydrochloride)

A multi-targeted anxiolytic drug with neuroprotective activities; binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as MAO-A (Kis = 5.9, 160, 0.97, and 3.6 µM, respectively, in a radioligand binding assay); decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice at 5 mg/kg; decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by MCAO at 0.3 and 3 mg/kg