BMS 470539 (hydrochloride)

Name: BMS 470539 (hydrochloride)
Brand: Cayman Chemical
SKU: CBSKU_100703458
Price: 356 GBP
Availability: InStock

Catalogue number:

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CAY22231-10 mg

Supplier:

Cayman Chemical

Size:

10 mg

Product is available in:

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£356.00

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Estimated delivery Mon 18 May
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This product is for research use only and is not for human consumption or therapeutic use.

CAS Number:

2341796-82-3

Purity:

≥98%

Formulation:

A crystalline solid

Molecular Formula:

C32H41N5O4 • 2HCl

Molecular Weight:

632.6

Alternative Names:

1-[1-(3-methyl-l-histidyl-o-methyl-d-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone, dihydrochloride

Product Description:

An MC1R agonist; induces cAMP accumulation in B16/F10 murine melanoma cells and in CHO cells overexpressing human MC1R (EC50s = 11.6 and 16.8 nM, respectively); inhibits LPS-induced TNF-α production in mice (ED50 = 10 µmol/kg, s.c.); reduces LPS-induced leukocyte infiltration and paw swelling in mouse models of lung inflammation and delayed-type hypersensitivity, respectively; decreases retinal damage in a mouse model of streptozotocin-induced diabetic retinopathy; increases striatal dopamine levels and decreases the number of striatal α-synuclein aggregates in a mouse model of Parkinson’s disease at 20 mg/kg