iCRT14
Catalogue number:
CAY22132-50 mg
Supplier:
Size:
50 mg
Product is available in:
£1005.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
677331-12-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H17N3O2S
Molecular Weight:
375.4
Alternative Names:
5-[[2,5-
- MSDS: View or download
Product Description:
An inhibitor of CRT (IC50 = 40.3 nM); inhibits β-catenin/Tcf4 binding (Kis = 53.51 µM); inhibits Notch, Hh, and JAK/STAT signaling (IC50s = 69.2, 194, and 70 nM, respectively); reduces proliferation and initial tumor growth rate in mouse xenografts of colon carcinoma (50 mg/kg i.p.); inhibits proliferation of leukemia cell lines; suppresses ATP-driven migration of the MCF-7 and MDA-MB-231 breast cancer cell lines
