£62.00
Estimated delivery Mon 13 Oct
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
60559-98-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C12H17N5
Molecular Weight:
231.3
Alternative Names:
n-cyano-n'-(1,1-dimethylpropyl)-n''-3-pyridinyl-guanidine
Product Description:
A potent activator of SUR2-Kir6 and KATP channels; activates SUR2-Kir6 channels (EC50 = 45 nM for SUR2B-Kir6 channel activation); highly selective for SUR2 over SUR1 isoforms (IC50s = 9-46 nM and 1.02 mM, respectively, in a radioligand binding assay); increases outflow facility, a marker of reduced intraocular pressure, in human eye anterior segments ex vivo; reduces infarct size in isolated rabbit hearts via activation of mitochondrial KATP channels (EC50s = 60-90 nM)
