APS-2-79 (hydrochloride)
Catalogue number:
CAY22137-10 mg
Supplier:
Size:
10 mg
Product is available in:
£203.00
Estimated delivery Wed 17 Dec
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2002381-31-7
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C23H21N3O3 • HCl
Molecular Weight:
423.9
Alternative Names:
6,7-dimethoxy
- MSDS: View or download
Product Description:
An inhibitor of KSR-dependent MAPK signaling; inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM); stabilizes KSR2 in an inactive state; reduces interactions between B-RAF and KSR2-MEK1 complexes; inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells at 5 µM; enhances the efficacy of trametinib, further reducing cell viability in K-Ras mutant HCT116 and A549 cell lines, but not B-RAF mutant SK-MEL-239 and A375 cell lines, at 1 µM
