8-Nitroguanine
Catalogue number:
CAY89295-1 mg
Supplier:
Size:
1 mg
Product is available in:
£154.00
Estimated delivery Tue 16 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
168701-80-2
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C5H4N6O3
Molecular Weight:
196.1
Alternative Names:
2-amino-
- MSDS: View or download
Product Description:
A nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by RNS during inflammation or in vitro; mutagenic and induces G:C to T:A transversion in DNA; stalls human DNA polymerase β and induces a 2:1 preference dA insertion over dC when placed into a primer template as an 8-nitroG:anti-G base pair; levels are increased in the lung tissue of mice with mutant K-Ras(G12V) that developed lung adenocarcinoma and in the lung tissue and peripheral lymphocyte DNA of cigarette smoke-exposed rats; levels are increased in the lung tissue of influenza or Sendai virus-infected mice and in colon epithelial cells of an IBD mouse model
