CB-839
Catalogue number:
CAY22038-5 mg
Supplier:
Size:
5 mg
Product is available in:
£73.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1439399-58-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C26H24F3N7O3S
Molecular Weight:
571.6
Alternative Names:
n-[5-[4-[6-
Product Description:
An orally bioavailable noncompetitive inhibitor of GLS1; inhibits GAC (IC50s 50s = 28 and 23 nM, respectively for brain and kidney) compared to GLS2 (IC50 > 1,000 nM for liver); antiproliferative against TNBC cell lines HCC1806 and MDA-MB-231 (IC50s = 49 and 26 nM, respectively), but not against estrogen receptor-positive cells T47D (IC50 > 1,000 nM); inhibits tumor growth by 61% in a patient-derived TNBC xenograft model (200 mg/kg, p.o.); antiproliferative against AML and in synergy with erlotinib against EGFR-driven NSCLC
