Iberdomide
Catalogue number:
CAY22615-5 mg
Supplier:
Size:
5 mg
Product is available in:
£176.00
Estimated delivery Thu 18 Sep
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1323403-33-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C25H27N3O5
Molecular Weight:
449.5
Alternative Names:
3s-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2h-isoindol-2-yl]-2,6-piperidinedione, cc-220
Product Description:
A cereblon modulator with an IC50 value of 60 nM in a competitive TR-FRET assay; has a higher affinity for cereblon than the related modulators lenalidomide (IC50 = 1,500 nM) and pomalidomide (IC50 = 1,200 nM) in the same assay; has a greater potency for degradation of the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) as well; does not degrade GSPT1 or CK1α
