LCL-161
Catalogue number:
CAY22420-10 mg
Supplier:
Size:
10 mg
Product is available in:
£399.00
Estimated delivery Tue 2 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1005342-46-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C26H33FN4O3S
Molecular Weight:
500.6
Alternative Names:
n-[(1s)-1-
Product Description:
A Smac mimetic and inhibitor of IAP family proteins; inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis (IC50s = 0.5-4 µM); enhances growth inhibition driven by PKC 412 in a mouse Ba/F3-FLT3-ITD-luc+ leukemia xenograft model; exhibits additive effects with the chemotherapeutic agents doxorubicin and cytarabine; inhibits growth of nilotinib-resistant leukemia cell lines and exhibits synergy with nilotinib in a Bcr-Abl expressing, 32D.p20-luc+ leukemia mouse xenograft model
