LCL-161
Catalogue number:
CAY22420-10 mg
Supplier:
Size:
10 mg
Product is available in:
£399.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1005342-46-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C26H33FN4O3S
Molecular Weight:
500.6
Alternative Names:
n-[(1s)-1-
Product Description:
A Smac mimetic and inhibitor of IAP family proteins; inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis (IC50s = 0.5-4 µM); enhances growth inhibition driven by PKC 412 in a mouse Ba/F3-FLT3-ITD-luc+ leukemia xenograft model; exhibits additive effects with the chemotherapeutic agents doxorubicin and cytarabine; inhibits growth of nilotinib-resistant leukemia cell lines and exhibits synergy with nilotinib in a Bcr-Abl expressing, 32D.p20-luc+ leukemia mouse xenograft model
