ARRY-520
Catalogue number:
CAY21883-10 mg
Supplier:
Size:
10 mg
Product is available in:
£236.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
885060-09-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C20H22F2N4O2S
Molecular Weight:
420.5
Alternative Names:
(2s)-2-(3-amino
Product Description:
A potent Eg5 inhibitor (IC50 = 6 nM); selective for Eg5 over a panel of 8 kinesins (IC50s = >100 µM) and a panel of 224 kinases at 10 µM; induces time-and dose-dependent cell death in HL-60, Jurkat, OCI-AML3, U937, and MOLM-13 leukemic cells; induces cell cycle arrest at the G2/M phase in a p53- and XIAP-independent manner in OCI-AML3 cells; inhibits blast colony formation of bone marrow samples derived from human AML patients; completely eliminates tumors in the RPMI-8226 multiple myeloma and HL-60 and MV4-11 AML mouse xenograft models at 20 mg/kg per day
