GSK805
Catalogue number:
CAY9002444-10 mg
Supplier:
Size:
10 mg
Product is available in:
£328.00
Estimated delivery Tue 2 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1426802-50-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C23H18Cl2F3NO4S
Molecular Weight:
532.4
Alternative Names:
n-[2,6-dichloro-
Product Description:
A RORγt inverse agonist (IC50 = 3.98 nM in a FRET assay); inhibits naïve CD4+ T cell differentiation into Th17 cells induced by IL-6, TGF-β1, and IL-23 at 0.5 µM; reduces viability in MDA-MB-468 cells at 2.5 µM; decreases levels of cholesterol in HCC70 cells at 2.5 µM; reverses hindlimb weakness and paralysis in a mouse model of MOG33-55- and complete Freund's adjuvant-induced EAE at 10 mg/kg per day
