GSK805
Catalogue number:
CAY9002444-1 mg
Supplier:
Size:
1 mg
Product is available in:
£62.00
Estimated delivery Mon 11 May
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1426802-50-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C23H18Cl2F3NO4S
Molecular Weight:
532.4
Alternative Names:
n-[2,6-dichloro-
Product Description:
A RORγt inverse agonist (IC50 = 3.98 nM in a FRET assay); inhibits naïve CD4+ T cell differentiation into Th17 cells induced by IL-6, TGF-β1, and IL-23 at 0.5 µM; reduces viability in MDA-MB-468 cells at 2.5 µM; decreases levels of cholesterol in HCC70 cells at 2.5 µM; reverses hindlimb weakness and paralysis in a mouse model of MOG33-55- and complete Freund's adjuvant-induced EAE at 10 mg/kg per day
