OTS514
Catalogue number:
CAY17053-1 mg
Supplier:
Size:
1 mg
Product is available in:
£223.00
Estimated delivery Wed 17 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1338540-63-8
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C21H20N2O2S
Molecular Weight:
364.5
Alternative Names:
9-[4-[(1r)-2-
Product Description:
An inhibitor of TOPK (IC50 = 2.6 nM); selectively inhibits growth of patient-derived AML cells over normal CD34+ cells; inhibits growth of small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM); increases survival in a peritoneal mouse dissemination model of ovarian cancer at 25 and 50 mg/kg; dose-dependently inhibits tumor growth in an A549 mouse xenograft model at 1, 2.5, and 5 mg/kg
