Hispidin

A polyphenol with diverse biological activities; scavenges radicals at 14.47 equivalents of trolox in a TEAC assay; inhibits transcriptional activity of NF-κB, decreases iNOS expression, and decreases generation of ROS in LPS-induced macrophage RAW 264.7 cells; inhibits apoptosis and increases insulin secretion in hydrogen peroxide-treated RINm5F pancreatic β-cells.; inhibits PKCβ (IC50 = 2 µM); inhibits BACE1 (IC50 = 4.9 µM) and PE (IC50 = 16 µM) but not other serine proteases when used at a concentration of 40 µM (0.6, 0, 8.2, and 3.1% inhibition of chymotrypsin, trypsin, elastase, and TACE, respectively)