AZD 3759
Catalogue number:
CAY19931-25 mg
Supplier:
Size:
25 mg
Product is available in:
£479.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1626387-80-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H23ClFN5O3
Molecular Weight:
459.9
Alternative Names:
(2r)-2,4-
Product Description:
A brain penetrant inhibitor of EGFR (IC50s = 0.3, 0.2, and 0.2 nM for wild-type, L858R-mutant, and exon 19 deletion-containing EGFRs, respectively); selective for EGFR over 115 other kinases, exhibiting 50s = 7.7 and 7.0 nM, respectively) but has no effect on H838 cells that express wild-type EGFR (GI50 = 21,556 nM); inhibits tumor growth by 78% and induces tumor regression at doses of 7.5 and 15 mg/kg, p.o., respectively in a PC-9 mouse model of NSCLC brain metastasis
