AZD 3759
Catalogue number:
CAY19931-25 mg
Supplier:
Size:
25 mg
Product is available in:
£479.00
Estimated delivery Mon 6 Jul
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1626387-80-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H23ClFN5O3
Molecular Weight:
459.9
Alternative Names:
(2r)-2,4-
Product Description:
A brain penetrant inhibitor of EGFR (IC50s = 0.3, 0.2, and 0.2 nM for wild-type, L858R-mutant, and exon 19 deletion-containing EGFRs, respectively); selective for EGFR over 115 other kinases, exhibiting 50s = 7.7 and 7.0 nM, respectively) but has no effect on H838 cells that express wild-type EGFR (GI50 = 21,556 nM); inhibits tumor growth by 78% and induces tumor regression at doses of 7.5 and 15 mg/kg, p.o., respectively in a PC-9 mouse model of NSCLC brain metastasis
