2'3'-cGAMP (sodium salt)

Name: 2'3'-cGAMP (sodium salt)
Brand: Cayman Chemical
SKU: CBSKU_100687030
Price: 277 GBP
Availability: InStock

Catalogue number:

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CAY19887-500 ug

Supplier:

Cayman Chemical

Size:

500 µg

Product is available in:

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£277.00

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Estimated delivery Wed 6 May
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This product is for research use only and is not for human consumption or therapeutic use.

CAS Number:

2734858-36-5

Purity:

≥98%

Formulation:

A solid

Molecular Formula:

C20H22N10O13P2 • 2Na

Molecular Weight:

718.375342

Alternative Names:

adenylyl-(3'→5')-2'-guanylic acid, cyclic nucleotide, disodium salt, 2'3'-cyclic gmp-amp, guanosine-adenosine 2',3'-cyclic monophosphate

Product Description:

A second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA; contains a non-canonical 2’5’-phosphodiester bond; binds tightly to the adapter protein STING (Kd = 3.79 nM) and induces IFN-β mRNA expression (EC50 = 19.4 nM in L929 cells)