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196597-26-9
≥98%
A crystalline solid
259.3
n-[2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]furan-8-yl]ethyl]-propanamide, tak-375
- Data sheet: View or download
- MSDS: View or download
A melatonin receptor agonist (Kis = 14, 112, and 23.1 pM for human MT1, human MT2, and chick forebrain receptors, respectively); selective for MT1 and MT2 over MT3 receptors (Ki = 2.65 µM for hamster brain MT3 receptors) as well as a panel of benzodiazepine, dopamine, and opiate receptors, ion channels, transporters, and enzymes when used at a concentration of 10 µM; stimulates cAMP production in CHO cells expressing human MT1 and MT2 receptors (IC50s = 21.2 and 53.4 pM, respectively); shortens latency to sleep onset and increases duration of sleep in free moving crab-eating macaques at 0.03 and 0.3 mg/kg; accelerates reentrainment of circadian rhythm in rats at 0.1 and 1 mg/kg
-20°C