Cyproheptadine (hydrochloride hydrate)

An antihistamine with antiserotonergic and anticholinergic activities; binds to histamine H1, muscarinic, and serotonin 5-HT2 receptors (Kis = 0.38, 1.26, and 0.83 nM, respectively, in radioligand binding assays); reduces histamine-induced spasms in isolated guinea pig ileum (IC75 = 0.0014 µg/ml); protects against intravenous histamine diphosphate-induced death (PD50 = 0.08 mg/kg) and delays induction of aerosolized histamine diphosphate-induced coughing (ED100sec = 0.29 mg/kg) in guinea pigs; inhibits the lysine methyltransferase SET7/9 (IC50 = 1 µM), decreasing the expression of estrogen receptor α (ERα) in MCF-7 cells