ORY-1001
Catalogue number:
CAY19136-500 ug
Supplier:
Size:
500 µg
Product is available in:
£46.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1431326-61-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C15H22N2 • 2HCl
Molecular Weight:
303.3
Alternative Names:
rel-
Product Description:
An LSD1 inhibitor (IC50 = 0.018 µM); selective for LSD1 over LSD2, MAO-A, and MAO-B (IC50s = >100 µM) but does inhibit spermine oxidase (IC50 = 7.4 µM); inhibits the imidazoline I2 receptor, norepinephrine and dopamine transporters, and L-type voltage-gated calcium channels (IC50s = 0.37, 2.4, 1.7, and 4.9 µM, respectively); induces accumulation of H3K4me2 in THP-1 cells (EC50 = 0.0022 µM); reduces viability in a panel of primary AML cells at 100 nM; increases survival in a PDX mouse model of T-ALL at 0.0125 mg/kg
