BB-Cl-Amidine (trifluoroacetate salt)
Catalogue number:
CAY17079-5 mg
Supplier:
Size:
5 mg
Product is available in:
£236.00
Estimated delivery Mon 3 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C26H26ClN5O • XCF3COOH
Molecular Weight:
459.97044
Alternative Names:
n-[(1s)-1-(1h-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide, trifluoroacetate salt
Product Description:
A pan PAD inhibitor; irreversibly inhibits PAD1-4 (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1, respectively); inhibits PMA-induced NET formation in mouse bone marrow-derived neutrophils at 20 and 200 µM; inhibits HSV-1-induced IFN-β production in mouse BMDMs at 1 µM; reduces diABZI STING agonist-1-induced BMDM IFN-β and TNF-α production in wild-type, Pad2-/-, and Pad4-/- mice at 10 mg/kg; increases survival, as well as reduces splenomegaly, myocarditis, and cardiac fibrosis in a Trex1D18N/D18N mouse model of AGS at 20 mg/kg per day
