BB-Cl-Amidine (trifluoroacetate salt)
Catalogue number:
CAY17079-5 mg
Supplier:
Size:
5 mg
Product is available in:
£236.00
Estimated delivery Mon 12 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C26H26ClN5O • XCF3COOH
Molecular Weight:
459.97044
Alternative Names:
n-[(1s)-1-
Product Description:
A pan PAD inhibitor; irreversibly inhibits PAD1-4 (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1, respectively); inhibits PMA-induced NET formation in mouse bone marrow-derived neutrophils at 20 and 200 µM; inhibits HSV-1-induced IFN-β production in mouse BMDMs at 1 µM; reduces diABZI STING agonist-1-induced BMDM IFN-β and TNF-α production in wild-type, Pad2-/-, and Pad4-/- mice at 10 mg/kg; increases survival, as well as reduces splenomegaly, myocarditis, and cardiac fibrosis in a Trex1D18N/D18N mouse model of AGS at 20 mg/kg per day
