TAE684
Catalogue number:
CAY17670-1 mg
Supplier:
Size:
1 mg
Product is available in:
£52.00
Estimated delivery Mon 4 May
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
761439-42-3
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Formula:
C30H40ClN7O3S
Molecular Weight:
614.2
Alternative Names:
5-chloro-n2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-n4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine, nvp-tae684
Product Description:
A selective ALK inhibitor that blocks the proliferation of ALCL-derived and ALK-dependent cell lines (IC50s = 2-5 nM); suppresses tumor growth in in vivo models of ALK-positive ALCL and neuroblastoma; also inhibits the activity of the Parkinson’s disease-linked LRRK2 (IC50s = 7.8 and 6.1 nM for wild-type and G2019S mutant LRRK2, respectively)
