This peptide is derived from tyrosinase-related protein 2 (TRP2) residues 180-188. TRP2 belongs to the melanocyte differentiation antigens and has been implicated as a target for immunotherapy of human as well as murine melanoma. Studies show that this TRP2 derived peptide can bind to mouse and human MHC class I molecules. Immunization with TRP2 peptide loaded dendritic cells (DCs) results in effective induction of antitumor immunity.
Proteins & Peptides
Peak Area by HPLC ≥95%
Park, J. et al. The EMBO J. 18, 3024 (1999); Bichsel, S. et al. J. Biol. Chem. 279, 35228 (2004)