Integrin-Binding Site, GRGDNP - ANA62049 - 1 mg - AnaSpec - proteins & peptides
Integrin-Binding Site, GRGDNP
Catalogue number:
ANA62049
Name:
Integrin-Binding Site, GRGDNP
Supplier:
Availability:
This RGD-containing sequence is integrin-binding site. RGD peptides are found in both extracellular matrix (ECM) (e.g., collagen, osteopontin, fibronectin, and vitronectin) and non-ECM proteins (e.g., disintegrins). RGD-containing peptides are recognized by several integrins. This peptide targets both alphavbeta3 and alpha5beta1 integrins. Interaction of the RGDN sequence with endothelial alpha5beta1 integrin causes endothelin-mediated arteriolar vasoconstriction. This peptide influences the IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) activation. It also controls the cardiac contractile function.
Data sheet:
Product Type:
Proteins & Peptides
Alternative Names:
GRGDNP
Storage Temp:
-20°C
Compound Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
614.6
Reference:
Mogford, J. et al. J. Clin. Invest. 100, 1647 (1997); Sasamoto, A. et al. Am. J. Physiol. Cell. Physiol. 288, C1012 (2005); Sarin, V. et al. J. Physiol. 564, 603 (2005).
UNSPSC Code:
12352202
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