This is the N-terminal fragment of b-Amyloid peptide amino acids 1 to 9. Omission of residues 1 to 9 from the full-length Alzheimer's b-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism. This b-Amyloid peptide fragment contains a functional B cell epitope, but lacks known T cell epitopes, which makes it an attractive candidate for the development of b-Amyloid vaccine that lacks the potential to induce autoimmune encephalitis.
Proteins & Peptides
Peak Area by HPLC ≥95%
Paravastu, A. et al. Biophys. J. 90, 4618 (2006); Zamora, E. et al. J. Immunol. 177, 2662 (2006).