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[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27) - ANA61937 - 1 mg - AnaSpec - proteins & peptides

[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)
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Size: 1 mg
£290.00
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Catalogue number:
ANA61937
Name:
[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)
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This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.

Data sheet:

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Product Type:
Proteins & Peptides
Alternative Names:
NF-(NMe-G)-A-(NMe-I)-L
Storage Temp:
-20°C
Compound Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
661.8
Reference:
Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).
UNSPSC Code:
12352202
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