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[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27) - ANA61937 - 1 mg - AnaSpec - proteins & peptides

[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)
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[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)

This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.

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Proteins & Peptides
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Compound Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).
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