*

[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)

Supplier:
Catalogue number:
ANA61937
Size:
1 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£320.00 Shipping is calculated in checkout

This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

661.8

Reference:

Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).

UNSPSC Code:

12352202

Sorry - there are no images available for this product.