This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-κB activation.
Proteins & Peptides
Peak Area by HPLC ≥95%
Nickoloff, B. et al. Cell Death Different. 9, 842 (2002).