7,8-Dihydroxyflavone

A flavone with diverse biological activities; binds to TrkB (Kd = 320 nM) and induces TrkB autophosphorylation in primary mouse hippocampal neurons; reduces neuronal apoptosis and reduces infarct volume in a mouse model of MCAO-induced ischemia-reperfusion injury at 5 mg/kg; reduces striatal nigral neuronal apoptosis in a mouse model of MPTP-induced Parkinson’s disease; increases survival, neocortical volume, and whole brain volume in an N171-82Q mouse model of Huntington’s disease at 5 mg/kg; reduces blood glucose levels, pancreatic vascular congestion, and inflammatory cell infiltration, as well as hepatic vascular congestion and DDIT3 and GRP78 levels in a mouse model of cafeteria diet-induced metabolic syndrome at 5 mg/kg per day, i.p.