Pacritinib
Catalogue number:
CAY16709-5 mg
Supplier:
Size:
5 mg
Product is available in:
£476.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
937272-79-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C28H32N4O3
Molecular Weight:
472.6
Alternative Names:
11-[2-(1-pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16e,21,23-decaene, sb1518
Product Description:
An inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively); blocks the activities of the FLT3 D835Y mutant, FLT3 with ITDs, and JAK2 with a V617F substitution (IC50s = 6, 20-180, and 220 nM, respectively); orally bioavailable, inhibiting tumor growth and metastasis in xenografts in mice
