SN-38
Catalogue number:
CAY15632-50 mg
Supplier:
Size:
50 mg
Product is available in:
£496.00
Estimated delivery Mon 4 May
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
86639-52-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H20N2O5
Molecular Weight:
392.4
Alternative Names:
(4s)-4,11-
Product Description:
An inhibitor of topoisomerase I and an active metabolite of irinotecan; induces topoisomerase I-dependent DNA cleavage in a cell-free assay at 0.1, 1, and 10 µM; induces DNA single-strand breaks in HT-29 cells at 200 nM; induces cytotoxicity in HT-29 cells (IC50 = 8.8 nM); reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model at 100 mg/kg per day
