EPZ5676
Catalogue number:
CAY16175-1 mg
Supplier:
Size:
1 mg
Product is available in:
£62.00
Estimated delivery Wed 10 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1380288-87-8
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C30H42N8O3
Molecular Weight:
562.7
Alternative Names:
5′-deoxy-5′-
- MSDS: View or download
Product Description:
A highly potent and selective inhibitor of DOT1L histone methyltransferase activity (Ki = 80 pM); inhibits the H3K79 methylation in various human leukemia cell lines (IC50s = 3-5 nM), decreasing MLL-fusion target gene expression and inhibiting proliferation; intravenous infusion of EPZ-5676 at a dose of 35 mg/kg can regress tumors in a rat xenograft model of MLL-rearranged leukemia
